[exim] 4xx from GMAIL for fatal errors

Hello exim users,

a mail with 33 recipients, some of them at gmail was sitting in the queue.
The Google recipients got
451-4.3.0 Multiple destination domains per transaction is unsupported.
or
452-4.2.2 The email account that you tried to reach is over quota.

Are there any configuration recipies known to deal with that situation i.e. taking the 451 and 452 from them as 5xx errors?

Thanks, Axel
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PGP-Key: CDE74120 ☀ computing @ chaos claudius