[exim] On host lookup fail connect if on blacklist

In Exim is there a method by which during or right after host lookup for
outbound email, if the host or domain ip is listed in a "blacklist
file", issue a fail?

I need a method of blacklisting email to certain sites I would think
this would be configurable in Exim.

Cpanel offers a blacklist of connecting SMTP servers, I need the
opposite, a black list of outgoing connections.