[exim] Problem with exim4

Hi, i'm using exim4 with a email client to send email. I have configurated
an account with a external server, is a mail.xxxx.com, at the beginning to
configure, I have a problem with the user and password, to the account
email, and I can't send any email, but the problema was mine, but now,
what I now the correct user and password, whenever I want to send a email
with mail -v xxxx@???, on the console I get this:

R=smarthost T=remote_smtp_smarthost defer (-53): retry time not reached
for any host

And I don't Know why it can be.

Someone know why it could be? or something I could do to fix?

Thank you very much