[Exim] retry time not reached for any host after a long fail…

Can anyone tell me what this error message means?

I have nothing in the queue for this host, nor do I see any errors to this
host until this morning. All other hosts in this router are working fine.

Error Message:
email@??? R=VPN_Router T=remote_smtp: retry time not reached for any
host after a long failure period

VPN_Router:
  driver = manualroute
  transport = remote_smtp
  route_list = ahost.biz 192.168.70.2:mail.ahost.biz byname ;\
        bhost.com 192.168.40.2:mail.bhost.com byname ;\
        chost.com 192.168.10.3:mail.chost.com byname ;\
        dhost.com 192.168.11.20:mail.ehost.com byname

Thank You

Terry Shows
Computer Software Specialists LLC
terry.shows@??? <mailto:terry.shows@csstn.com>