[Exim] Mail routing error...

Hello All,

I am trying to send mail through a php script. I get this error while
sending mail. Please can anyone help me.

2003-04-15 13:09:20 195TwE-00073K-00 ** system@???
R=lookuphost T=remote_smtp: SMTP error from remote mailer after RCPT
TO:<system@???>: host eluminoustechnologies.com
[162.42.208.49]: 550 cannot route to sender address <root@???>
2003-04-15 13:09:20 195TwE-00073M-00 <= <> R=195TwE-00073K-00 U=root P=local
S=1299
2003-04-15 13:09:20 195TwE-00073K-00 Error message sent to
root@???
2003-04-15 13:09:20 195TwE-00073K-00 Completed
2003-04-15 13:09:20 195TwE-00073M-00 == root@??? T=local_delivery
defer (13): Permission denied: failed to chdir to /root

Thank you,

Tina...