[Exim] multiple ip address (re)routing

Hi Guys..

Heres a question, lets say a client has a machine running exim 4,
and has 3 network cards..

[isp1][isp2]
   |         |
[exim4box]
       |
[internal network]

Is it possible to configure exim to route specific domains through one isp
and other domains through the other? (each isp is on a different ip and each
different ip is on a different network card..)

Regards
Cami ;)