[Exim] Header Data

I have this line in my configuration file:
sender_reject = /usr/exim/reject
in this file(reject) I have entries like

values@???
*@pm0.net
etc...

My question, does this reject clause block the From:,Return-path: or
the Reply-To:

I am going through emails that I want to add to my reject list and I am
taking out the From: header and adding that info to my reject file.
It seems some are sneaking in still. Is it because it doesn't reject on
the From: header?

--
Joseph Kezar