[exim] relay not permitted error

Hi,

When I try to send mail to myfriend@??? I get the error:

May 24 05:29:33 host1 exim[6011]: 2019-05-24 10:59:33 H=([192.168.1.1]) [202.153.45.34] X=TLSv1.2:ECDHE-RSA-AES256-GCM-SHA384:256 CV=no F=<me@???> rejected RCPT <myfriend@???>: relay not permitted
May 24 05:29:33 host1 exim[6011]: 2019-05-24 10:59:33 H=([192.168.1.1]) [202.153.45.34] X=TLSv1.2:ECDHE-RSA-AES256-GCM-SHA384:256 CV=no F=<me@???> rejected RCPT <myfriend@???>: relay not permitted

I also tried setting:

hostlist relay_from_hosts = 127.0.0.1 : localhost : MAIN_RELAY_NETS

and restarted exim server but it gave the same error.

... Necktwi