[exim] Smtp outgoing mail problem

Now i am using exim4 mail.Actually i upgrade it from exim3 Now the error
showing mainlog T=remote_smtp_smarthost :Smtp error from remote mailserver
host smtp.isp.com 553 sorry delaying denied from your location
and the message is frozen.I haven,t changed any settings but i saw some
settings in /etc/exim4/conf.d/main/00_local_macros

AUTH_CLIENT_ALLOW_NOTLS_PASSWORDS=1
MAIN_TLS_ENABLE=1
Please give me a solution.