[Exim] Exim urgent problem

Hello,
We have this problem for all host and all email are in queue (~600).

2003-07-02 00:26:13 19XOon-0002kg-I3 == ap.glaizal-cpecf@???
<apglaizal@???> R=lookuphost T=remote_smtp defer (-53): retry
time not reached for any host

Any idea?

A telnet connection to this port is ok.
I don't know why there is this error.

All messages in queue have the same error :/

Thanks